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Description
NeuroD1 Recombinant Rabbit mAb (SDT-3843-59)Product Specification Host Rabbit Antigen NeuroD1 Synonyms Neurogenic differentiation factor 1; NeuroD; NeuroD1Alternative nameClass A basic helix loop helix protein 3 (bHLHa3); BHLHA3; NEUROD1 Immunogen Synthetic Peptide Location Cytoplasm, Nucleus Accession Q13562 Clone Number SDT 3843 59 Antibody Type Recombinant mAb Isotype IgG Application WB, IHC P Reactivity Hu, Ms, Rt Positive Sample Y79, TC 6, mouse cerebellum, rat cerebellum Purification
Product Specification
| Host | Rabbit |
| Antigen | NeuroD1 |
| Synonyms | Neurogenic differentiation factor 1; NeuroD; NeuroD1Alternative nameClass A basic helix-loop-helix protein 3 (bHLHa3); BHLHA3; NEUROD1 |
| Immunogen | Synthetic Peptide |
| Location | Cytoplasm, Nucleus |
| Accession | Q13562 |
| Clone Number | SDT-3843-59 |
| Antibody Type | Recombinant mAb |
| Isotype | IgG |
| Application | WB, IHC-P |
| Reactivity | Hu, Ms, Rt |
| Positive Sample | Y79, β-TC-6, mouse cerebellum, rat cerebellum |
| Purification | Protein A |
| Concentration | 0.5 mg/ml |
| Conjugation | Unconjugated |
| Physical Appearance | Liquid |
| Storage Buffer | PBS, 40% Glycerol, 0.05% BSA, 0.03% Proclin 300 |
| Stability & Storage | 12 months from date of receipt / reconstitution, -20 °C as supplied |
Dilution
| application | dilution | species |
| WB | 1:1000 | Hu, Ms, Rt |
| IHC-P | 1:250 | Hu, Ms, Rt |
Background
NeuroD1 (Neurogenic Differentiation 1) is a basic helix-loop-helix (bHLH) transcription factor that serves as a master regulator in the development of the nervous system and pancreas, primarily functioning to commit progenitor cells to a neuronal fate by activating downstream neurogenic genes while simultaneously suppressing glial differentiation pathways. Expressed transiently during embryogenesis in specific regions of the central and peripheral nervous systems, NeuroD1 binds to E-box DNA sequences as a heterodimer with E-proteins to drive the expression of targets essential for neuronal maturation, migration, and survival, making it critical for the formation of structures such as the hippocampus, cerebellum, and retina; beyond its developmental role, it is also pivotal in pancreatic beta-cell differentiation and has been identified as a potent reprogramming factor capable of directly converting non-neuronal cells, including astrocytes and fibroblasts, into functional neurons, thereby holding significant therapeutic potential for treating neurodegenerative diseases and repairing neural injury through endogenous regeneration or cell replacement strategies.
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