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Description
Eotaxin/CCL11 Protein, HumanProduct Specification Species Human Synonyms C C motif chemokine 11, Eosinophil chemotactic protein, Small inducible cytokine A11 Accession P51671 Amino Acid Sequence Gly24 Pro97 Expression System E. coli Molecular Weight 10kDa (Reducing) Purity 95% by SDS PAGE Endotoxin <0. 1EU g Conjugation Unconjugated Tag No Tag Physical Appearance Lyophilized Powder Storage Buffer PBS, pH7. 4. Reconstitution Reconstitute at 0. 1 1 mg ml according to the size in
Product Specification
| Species | Human |
| Synonyms | C-C motif chemokine 11, Eosinophil chemotactic protein, Small-inducible cytokine A11 |
| Accession | P51671 |
| Amino Acid Sequence | Gly24-Pro97 |
| Expression System | E.coli |
| Molecular Weight | 10kDa (Reducing) |
| Purity | ＞95% by SDS-PAGE |
| Endotoxin | <0.1EU/μg |
| Conjugation | Unconjugated |
| Tag | No Tag |
| Physical Appearance | Lyophilized Powder |
| Storage Buffer | PBS, pH7.4. |
| Reconstitution | Reconstitute at 0.1-1 mg/ml according to the size in ultrapure water after rapid centrifugation. |
| Stability & Storage | · 12 months from date of receipt, lyophilized powder stored at -20 to -80℃. · 3 months, -20 to -80℃ under sterile conditions after reconstitution. · 1 week, 2 to 8℃ under sterile conditions after reconstitution. · Please avoid repeated freeze-thaw cycles. |
| Reference | Acta Neurol Belg. 2022; 122(4): 865–869. Pharmaceuticals (Basel). 2020 Sep; 13(9): 230. |
Background
Eotaxin/CCL11, produced by eosinophils, B-cells, fibroblasts, endothelial cells, macrophages, chondrocytes and other cells, is a member of the eotaxin family that is chemotactic agents for eosinophils and participate in innate immunity. It is induced by T helper-2 cytokines, like IL-13, IL-10 and IL-4, then transported from the blood to the brain through the Blood-Brain Barrier (BBB). Eotaxin/CCL11 may exert physiological and pathological functions in the central nerve system, and may induce neuronal cytotoxicity effects by inducing the production of reactive oxygen species (ROS) in microglia cells. Plasma levels of CCL11 elevated in neuroinflammation and neurodegenerative disorders.
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