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Description
PE-Cy7 Rat Anti-Mouse CD8α Antibody (S-R540)Product Specification Host Rat Antigen CD8 Synonyms T cell surface glycoprotein CD8 alpha chain; T cell surface glycoprotein Lyt 2; CD8a; Lyt 2; Lyt2 Location Cell membrane Accession P01731 Clone Number S R540 Antibody Type Rat mAb Isotype IgG2a,k Application FCM Reactivity Ms Positive Sample BALB c mouse splenocytes Purification Protein G Concentration 0. 02mg ml Conjugation PE Cy7 Physical Appearance Liquid Storage Buffer PBS, 1% BSA, 0. 3% Proclin
Product Specification
| Host | Rat |
| Antigen | CD8α |
| Synonyms | T-cell surface glycoprotein CD8 alpha chain; T-cell surface glycoprotein Lyt-2; CD8a; Lyt-2; Lyt2 |
| Location | Cell membrane |
| Accession | P01731 |
| Clone Number | S-R540 |
| Antibody Type | Rat mAb |
| Isotype | IgG2a,k |
| Application | FCM |
| Reactivity | Ms |
| Positive Sample | BALB/c mouse splenocytes |
| Purification | Protein G |
| Concentration | 0.02mg/ml |
| Conjugation | PE-Cy7 |
| Physical Appearance | Liquid |
| Storage Buffer | PBS, 1% BSA, 0.3% Proclin 300 |
| Stability & Storage | 12 months from date of receipt / reconstitution, 2 to 8 °C as supplied. |
Dilution
| application | dilution | species |
| FCM | 5μl per million cells in 100μl volume | Ms |
Background
CD8α is a crucial immune glycoprotein that plays a vital role in the immune system as a co-receptor for the T-cell receptor (TCR) on T cells. It is typically found in a heterodimer with CD8β or as a homodimer in certain cell types. CD8α binds to MHC class I molecules on antigen-presenting cells (APCs) to facilitate the recognition of intracellular pathogens, such as viruses and cancer cells, by cytotoxic T lymphocytes (CTLs). This interaction is essential for T cell activation and the initiation of downstream signaling pathways, including the recruitment of LCK kinase. Additionally, CD8α is expressed on intraepithelial lymphocytes (IELs) in the gut, where it contributes to mucosal immunity and the maintenance of gut barrier integrity.
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