SKU: 47863423892

Invivo anti-Mouse CD314 (NKG2D) Recombinant mAb

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Description

Invivo anti-Mouse CD314 (NKG2D) Recombinant mAbProduct Specification Host Rat Antigen CD314 (NKG2D) Synonyms NKG2 D type II integral membrane protein; Killer cell lectin like receptor subfamily K member 1; NK cell receptor D; NKG2 D activating NK receptor; Nkg2d; Klrk1 Location Cell membrane Accession O54709 Clone Number S R664 Antibody Type Rat mAb Isotype Rat IgG1,k Application FCM, in vivo CD314 blockade, in vitro CD314 blockade Reactivity Ms Positive Sample C57BL 6 mouse splenocytes

Product Specification


Host Rat
Antigen CD314 (NKG2D)
Synonyms NKG2-D type II integral membrane protein; Killer cell lectin-like receptor subfamily K member 1; NK cell receptor D; NKG2-D-activating NK receptor; Nkg2d; Klrk1
Location Cell membrane
Accession O54709
Clone Number S-R664
Antibody Type Rat mAb
Isotype Rat IgG1,k
Application FCM, in vivo CD314 blockade, in vitro CD314 blockade
Reactivity Ms
Positive Sample C57BL/6 mouse splenocytes
Purification Protein G
Concentration 5 mg/ml
Purity >95%(Determined by SDS-PAGE)
Endotoxin <1EU/mg
Conjugation Unconjugated
Physical Appearance Liquid
Storage Buffer

PBS pH7.4, containing no preservative
Stability & Storage

2 to 8 °C for 2 weeks under sterile conditions;
-20 °C for 3 months under sterile conditions;
-80 °C for 24 months under sterile conditions.
Please avoid repeated freeze-thaw cycles.

Dilution


application dilution species
FCM 1:500 Ms

Background

NKG2D is a type II transmembrane C-type lectin-like receptor expressed as a disulfide-linked homodimer on virtually all human and mouse NK cells, γδ T cells, and CD8+ αβ T cells; upon engagement by stress-inducible MHC class I–related ligands (MICA/B, ULBPs in humans; Rae-1, H60, Mult1 in mice) it couples to the DAP10 (and in mouse also DAP12) adaptor to deliver phosphotyrosine signals that powerfully lower activation thresholds, costimulate cytotoxicity, and drive proliferation and cytokine release, thereby forming a central surveillance axis that eliminates transformed, infected, or otherwise stressed cells but also contributes to immune-mediated pathologies when ligand expression becomes chronic.

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SKU: 47863423892

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4.7 ★★★★★
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Product Reviews
J
Verified Purchase
Jane Doe
San Leandro, US
★★★★★ 5
Ordinary People, Extraordinary Experiences
Format: Hardcover
A beautiful and interesting coffee table book. Whether you're a believer or not,the many photos of the Swiss countryside are lovely, and the photos and remarks from ordinary people like us are interesting and moving. Experiencer or not, a worthwhile purchase.
WAS THIS REVIEW HELPFUL?YesReportShare
Reviewed in the United States on August 7, 2025
C
Verified Purchase
Carla McBeath
Lake Worth, US
★★★★★ 5
I read the quotations first
Format: Hardcover
Of all the stories I have read about those who experienced extraterrestrial life, and all those who told those stories, Billy Meier's story is the most authentic. This book is a beautifully written and photographed narrative of Meier's relationship with various people from the stars, over a period of time. Billy himself reminded me of my best friends in the 1960's and 70's--quiet and kind. But the most remarkable part of this book, apart from the extraordinary photographs, is that there are quotations from the extraterrestrial visitors themselves, which are worth reading, in order. Yes, you might still not believe this happened, but you cannot help but absorb insights in those quotations. You will not forget them.
WAS THIS REVIEW HELPFUL?YesReportShare
Reviewed in the United States on July 17, 2024
R
Verified Purchase
Richard Borutta
Pawtucket, US
★★★★★ 5
A Civilization in Transition: Can Humans Make the "Jump" to Hyperspace?
Format: Hardcover
Though there is ample evidence to suggest that humanity has been visited by "off-planet" beings or relatives since as far back as any recorded history in stone or on paper, with the advent of technologies bringing us closer to an enlightenment or a destruction, UFO/UAP events seem to becoming more frequent. And more accepted. When UFO...CONTACT FROM THE PLEIADES v I and II were first published 45 years ago few people had a personal computer in their homes let alone any digital technology whatsoever. There were gains in human rights protections along with ecological study and the awareness of the importance to "love our Mother." (Earth) So it may not be so unreal to consider that one specific human, a farmer in rural Switzerland was chosen for multiple contact events and allowed to capture photographs, audio recordings, films and even metallic samples from OP visitors for the purpose of helping humanity expand its consciousness to the next level. This reissue tells such a story with vivid photography, detailed analysis and skilled reporting having used the most advanced non-civilian equipment available at the highest levels in its day. Furthermore, time has only affirmed that none of the photographs or video from the Billy Meier case have proved to be fake or forged in any known way. This is the book for searchers interested in the "nuts and bolts" of ufology. And yet... Whether you believe in UFOs or off-planet visitors is really beside the point here. The deeper point - and the not so hidden purpose revealed through the messages given to Billy Meier from Semjase, a Pleiadean traveler who contacted Meier over 100 times in the 1970s - is to consider if each one of us is capable of suspending disbelief long enough to be curious, which takes an open heart. And if we open our hearts, how can we do harm to ourselves, our planet, or others in the universe? And if we can achieve "do no harm" what else could we achieve? Hyperspace? Telepathy? A humane civilization where no one goes hungry or homeless? The point is whether or not we are ready, collectively, to expand our consciousness. After reading this book, I want to take that leap!
WAS THIS REVIEW HELPFUL?YesReportShare
Reviewed in the United States on May 3, 2024
J
Verified Purchase
JFG
Draper, US
★★★★★ 5
A wonderful book !l
Format: Hardcover
No doubt the subject of UFO's and ET's is a challenging subject. But the Billy Meier story is certainly one of the very best. This book is masterwork that warrants the highest rating. The photos are extraordinary and the story line is superb. Buy a copy or several for yourself and for gifts . A. very happy customer ....indeed.
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Reviewed in the United States on October 22, 2024
E
Verified Purchase
EAB
Alexandria, US
★★★★★ 5
Amazingly well written
Format: Hardcover
Nice book. Pictures and honest interviews and reports via credible down to earth persons. They don't weigh you down with hundreds of pages to read. Well done
WAS THIS REVIEW HELPFUL?YesReportShare
Reviewed in the United States on September 15, 2024

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