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Description
GARP&Latent TGF-β1 Heterotrimer His Tag Protein, MouseProduct Specification Species Mouse Synonyms RRC32 & TGF beta 1; LRRC32&TGFB1 Accession G3XA59P04202 Amino Acid Sequence GARP: Ile18 Asn628, with C terminal His Latent TGF 1: Leu30 Ser390 Expression System HEK293 Molecular Weight 80 93kDa GARP(Reducing), 35 50kDa LAP(Reducing), 10 14kDa mature TGF 1 (Reducing) Purity 95% by SDS PAGE Endotoxin <0. 1EU g Conjugation Unconjugated Tag His Tag Physical Appearance Lyophilized Powder Storage Buffer PBS, pH7.
Product Specification
| Species | Mouse |
| Synonyms | RRC32 & TGF-beta 1; LRRC32&TGFB1 |
| Accession | G3XA59、P04202 |
| Amino Acid Sequence | GARP: Ile18-Asn628, with C-terminal His Latent TGF-β1: Leu30-Ser390 |
| Expression System | HEK293 |
| Molecular Weight | 80-93kDa GARP(Reducing), 35-50kDa LAP(Reducing), 10-14kDa mature TGF-β1 (Reducing) |
| Purity | ＞95% by SDS-PAGE |
| Endotoxin | <0.1EU/μg |
| Conjugation | Unconjugated |
| Tag | His Tag |
| Physical Appearance | Lyophilized Powder |
| Storage Buffer | PBS, pH7.4. |
| Reconstitution | Reconstitute at 0.1-1 mg/ml according to the size in ultrapure water after rapid centrifugation. |
| Stability & Storage |
· 12 months from date of receipt, lyophilized powder stored at -20 to -80℃. · 3 months, -20 to -80℃ under sterile conditions after reconstitution. · 1 week, 2 to 8℃ under sterile conditions after reconstitution. · Please avoid repeated freeze-thaw cycles. |
| Reference | 1. Alessandra Metelli, Mohammad Salem, Caroline H Wallace, Bill X Wu, Anqi Li. Immunoregulatory functions and the therapeutic implications of GARP-TGF-β in inflammation and cancer. J Hematol Oncol. 2018 Feb 20;11(1):24. |
Background
GARP (glycoprotein-A repetitions predominant) is a type I transmembrane cell surface docking receptor for latent transforming growth factor-β (TGF-β) that is abundantly expressed on regulatory T lymphocytes and platelets. By binding to LTGF-β, GARP acts as a docking receptor that concentrates LTGF-β on the cell surface and enhances its final activation. The function of GARP has been extensively studied on regulatory T lymphocytes (Tregs), where it complexes with αVβ8 integrins to release active TGF-β from the surface of the cells. Via this function, GARP was shown to be involved in enhancing the suppressive phenotype of Tregs and in maintaining Treg-mediated peripheral tolerance.
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