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Description
FITC Mouse Anti-Human CD62L Antibody (S-937-77)Product Specification Host Mouse Antigen CD62L Synonyms L selectin, CD62 antigen like family member L, Leukocyte adhesion molecule 1 (LAM 1), Leukocyte surface antigen Leu 8, Leukocyte endothelial cell adhesion molecule 1 (LECAM1), Lymph node homing receptor, TQ1, gp90 MEL, SELL, LNHR, LYAM1 Immunogen Recombinant Protein Location Cell membrane Accession P14151 Clone Number S 937 77 Antibody Type Mouse mAb Isotype IgG1,k Application FCM Reactivity Hu
Product Specification
| Host | Mouse |
| Antigen | CD62L |
| Synonyms | L-selectin, CD62 antigen-like family member L, Leukocyte adhesion molecule 1 (LAM-1), Leukocyte surface antigen Leu-8, Leukocyte-endothelial cell adhesion molecule 1 (LECAM1), Lymph node homing receptor, TQ1, gp90-MEL, SELL, LNHR, LYAM1 |
| Immunogen | Recombinant Protein |
| Location | Cell membrane |
| Accession | P14151 |
| Clone Number | S-937-77 |
| Antibody Type | Mouse mAb |
| Isotype | IgG1,k |
| Application | FCM |
| Reactivity | Hu |
| Positive Sample | human PBMC |
| Purification | Protein G |
| Concentration | 0.05mg/ml |
| Conjugation | FITC |
| Physical Appearance | Liquid |
| Storage Buffer | PBS, 25% Glycerol, 1% BSA, 0.3% Proclin 300 |
| Stability & Storage | 12 months from date of receipt / reconstitution, 2 to 8 °C as supplied. |
Dilution
| application | dilution | species |
| FCM | 5μl per million cells in 100μl volume | Hu |
Background
CD62L, also known as L-selectin, is a type-I transmembrane glycoprotein and a member of the selectin family of adhesion molecules, primarily expressed on the surface of leukocytes such as T cells, B cells, and natural killer cells. It plays a crucial role in leukocyte homing and immune cell localization, facilitating the initial adhesion and rolling of white blood cells to endothelial cells during inflammation. CD62L is essential for the migration of naïve and central memory T cells into secondary lymphoid organs like lymph nodes, where it helps initiate and regulate immune responses. Additionally, CD62L serves as a phenotypic marker for central memory T cells, which have higher expression levels of this molecule and can rapidly respond to antigen re-exposure. In cancer immunotherapy, modulating CD62L expression can enhance T cell infiltration into the tumor microenvironment, improving treatment efficacy.
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