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Description
Biotinylated LAIR1 Fc&Avi Tag Protein, HumanProduct Specification Species Human Synonyms LAIR1, CD305 Accession Q6GTX8 Amino Acid Sequence Gln22 His163, with C terminal human IgG Fc & Avi Tag
Product Specification
| Species | Human |
| Synonyms | LAIR1, CD305 |
| Accession | Q6GTX8 |
| Amino Acid Sequence | Gln22-His163, with C- terminal human IgG Fc & Avi Tag QEEDLPRPSISAEPGTVIPLGSHVTFVCRGPVGVQTFRLERESRSTYNDTEDVSQASPSESEARFRIDSVSEGNAGPYRCIYYKPPKWSEQSDYLELLVKETSGGPDSPDTEPGSSAGPTQRPSDNSHNEHAPASQGLKAEHIEGRMDPKSSDKTHTCPPCPAPELLGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEVHNAKTKPREEQYNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKALPAPIEKTISKAKGQPREPQVYTLPPSRDELTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSPGKGLNDIFEAQKIEWHE |
| Expression System | HEK293 |
| Molecular Weight | 55-60kDa |
| Purity | >95% by SDS-PAGE |
| Endotoxin | <0.1EU/μg |
| Conjugation | Biotin |
| Tag | Human Fc Tag, Avi Tag |
| Physical Appearance | Lyophilized Powder |
| Storage Buffer | PBS, pH7.4 |
| Reconstitution | Reconstitute at 0.1-1 mg/ml according to the size in ultrapure water after rapid centrifugation. |
| Stability & Storage | · 12 months from date of receipt, lyophilized powder stored at -20 to -80℃. · 3 months, -20 to -80℃ under sterile conditions after reconstitution. · 1 week, 2 to 8℃ under sterile conditions after reconstitution. · Please avoid repeated freeze-thaw cycles. |
| Reference |
1、Meyaard L. et al. (2001) The epithelial cellular adhesion molecule (Ep-CAM) is a ligand for the leukocyte-associated immunoglobulin-like receptor (LAIR). J Exp Med. 194(1): 107-112. 2、Xu M. et al. (2000) Identification and characterization of leukocyte-associated Ig-like receptor-1 as a major anchor protein of tyrosine phosphatase SHP-1 in hematopoietic cells. J Biol Chem. 275(23): 17440-6. |
Background
Leukocyte-associated immunoglobulin-like receptor-1 (LAIR-1) is a type I glycoprotein of 287 amino acids containing a single extracellular Ig-like domain followed by a stalk region connected to the single transmembrane domain and 2 cytoplasmic immunoreceptor tyrosine-based inhibitory motifs that relay the inhibitory signal. LAIR-1 is expressed on almost all immune cells, including NK cells, T cells, B cells and mono-cytes, monocyte-derived dendritic cells, eosinophils, and basophils and mast cells. LAIR-1 binds both transmembrane and extracellular matrix collagens. The mLAIR-1 gene maps to the proximal end of mouse chromosome 7 in a region syntenic with human chromosome 19q13.4 where the LRC is located. LAIR-1 are involved in controlling the balance of the immune system to prevent improper activation or overactivation, which may result in tissue damage or autoimmune diseases. LAIR1 has been shown to inhibit T and NK cell activation mediated by several activating receptors. Furthermore, it has been shown that LAIR1 can deliver an inhibiting signal on intracellular free calcium concentration and immunoglobulin (Ig) production induced by the engagement of B cell antigen receptors (BCR).
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4.2 ★★★★★
Based on 9 reviews
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Product Reviews
★★★★★ 5
Pink IPad Case
Color: Pink
Great case. My iPad feels very safe in this case compared to my other ones. Easy to clean and the color matches the picture.
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Reviewed in the United States on June 8, 2026
★★★★★ 5
Great product
Color: Navy Blue
Awesome product. It does everything I need it to. Very smooth and stylish as well.
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Reviewed in the United States on May 12, 2026
★★★★★ 4
keyboard and case is phenomenal, trackpad is borderline unfunctional
Color: Black
I bought this case, because of the keyboard and trackpad, i wanted to use my ipad more like a laptop. the keyboard is phenomenal and certaintly better than other cheap ipad keyboards i have tried, I can actually use this one without having to repeatedly slam or hard press certain keys and can actually have a flow of typing. additionally, everything else regarding the case itself is amazing. it isnt cumbersome or bulky and it is very easy to swap between ipad and laptop mode on the fly. the trackpad however is genuinely unusable. the sensitivity on the trackpad is horrid and I cannot figure out how to change it, and additionally, clicking using the trackpad is outright impossible. you try to left click, it registers as a right click, or you try to click and it instead snaps your cursor to the bottom of the screen instead. it is also impossible to use any gesture functions with the trackpad, even something as simple as scrolling up and down or left to right is impossible. it is outright impossible to have any kind of workflow using the trackpad. it is unfortunately just a lot easier to use the keyboard and touch screen! its a shame that the keyboard and case itself is very nice too, so I will now have to spend more money on a separate mouse, which is additionally ANOTHER item i will have to carry around, just to make what I already bought work the way I expected.
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Reviewed in the United States on June 4, 2026
★★★★★ 5
Great quality at a great price range!
Color: Navy Blue
Works very well for the day to day. Great quality at a great price range. Would definitely buy again if needed.
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Reviewed in the United States on May 14, 2026
★★★★★ 5
Solid case.
Color: Sky-Blue
Love this case. Fits great and the color is great! The keyboard is nice and it even has a little spot for a stylist.
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Reviewed in the United States on June 3, 2026