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Description
Phospho-TAK1 (Ser412) Recombinant Rabbit mAb (S-3334-138)Product Specification Host Rabbit Antigen Phospho TAK1 (Ser412) Synonyms Mitogen activated protein kinase kinase kinase 7; Transforming growth factor beta activated kinase 1 (TGF beta activated kinase 1); TAK1; MAP3K7 Immunogen Synthetic Peptide Location Cytoplasm, Cell membrane Accession O43318 Clone Number S 3334 138 Antibody Type Recombinant mAb Isotype IgG Application WB Reactivity Hu, Ms, Rt, Mk Positive Sample HeLa (treated with 100 nM Calyculin
Product Specification
| Host | Rabbit |
| Antigen | Phospho-TAK1 (Ser412) |
| Synonyms | Mitogen-activated protein kinase kinase kinase 7; Transforming growth factor-beta-activated kinase 1 (TGF-beta-activated kinase 1); TAK1; MAP3K7 |
| Immunogen | Synthetic Peptide |
| Location | Cytoplasm, Cell membrane |
| Accession | O43318 |
| Clone Number | S-3334-138 |
| Antibody Type | Recombinant mAb |
| Isotype | IgG |
| Application | WB |
| Reactivity | Hu, Ms, Rt, Mk |
| Positive Sample | HeLa (treated with 100 nM Calyculin A for 10 minutes and 20 ng/ml human IL-1ß for 10 minutes), K562, C2C12, C6, COS-7 |
| Purification | Protein A |
| Concentration | 2 mg/ml |
| Conjugation | Unconjugated |
| Physical Appearance | Liquid |
| Storage Buffer | PBS, 40% Glycerol, 0.05% BSA, 0.03% Proclin 300 |
| Stability & Storage | 12 months from date of receipt / reconstitution, -20 °C as supplied |
Dilution
| application | dilution | species |
| WB | 1:1000 | Hu, Ms, Rt, Mk |
Background
Phospho-TAK1 (Ser412) is the activated form of transforming growth factor-β-activated kinase 1 (TAK1, also known as MAP3K7) following phosphorylation at serine residue 412, representing the activation state of this serine/threonine kinase signaling pathway. Ser412 is located within the activation loop region of TAK1, and its phosphorylation is critical for TAK1 kinase activity. When cells are stimulated by inflammatory cytokines (such as IL-1β, TNF-α), TGF-β, or various stress signals, TAK1 is activated through ubiquitination-dependent mechanisms. Phosphorylation at Ser412 promotes the interaction of TAK1 with its cofactors TAB1/TAB2/TAB3, subsequently activating downstream NF-κB and MAPK (including JNK and p38) signaling pathways, thereby regulating diverse biological processes such as inflammatory responses, apoptosis, autophagy, and fibrosis. Studies have shown that aberrant phosphorylation at Ser412 is closely associated with sustained activation of TAK1 in autoimmune diseases, inflammatory bowel disease, liver fibrosis, and various cancers.
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