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Description
Biotinylated CD4/LEU3 His&Avi Tag Protein, CynomolgusProduct Specification Species Cynomolgus Synonyms T4, IMD79, Leu 3, OKT4D, CD4mut Accession P79185 Amino Acid Sequence Lys26 Pro396, with C terminal His and Avitag Expression System HEK293 Molecular Weight 50 55kDa (Reducing) Purity 95% by SDS PAGE Endotoxin <1EU g Conjugation Biotin Tag Avi Tag, His Tag Physical Appearance Lyophilized Powder Storage Buffer PBS, pH7. 4. Reconstitution Reconstitute at 0. 1 1 mg ml according to the size in ultrapure
Product Specification
| Species | Cynomolgus |
| Synonyms | T4, IMD79, Leu-3, OKT4D, CD4mut |
| Accession | P79185 |
| Amino Acid Sequence | Lys26-Pro396, with C-terminal His and Avitag |
| Expression System | HEK293 |
| Molecular Weight | 50-55kDa (Reducing) |
| Purity | ＞95% by SDS-PAGE |
| Endotoxin | <1EU/μg |
| Conjugation | Biotin |
| Tag | Avi Tag, His Tag |
| Physical Appearance | Lyophilized Powder |
| Storage Buffer | PBS, pH7.4. |
| Reconstitution | Reconstitute at 0.1-1 mg/ml according to the size in ultrapure water after rapid centrifugation. |
| Stability & Storage | · 12 months from date of receipt, lyophilized powder stored at -20 to -80℃. · 3 months, -20 to -80℃ under sterile conditions after reconstitution. · 1 week, 2 to 8℃ under sterile conditions after reconstitution. · Please avoid repeated freeze-thaw cycles. |
| Reference | 1. Gavin R Owen, (2016) Human CD4 Metastability Is a Function of the Allosteric Disulfide Bond in Domain 2. Biochemistry. 55(15):2227-37. |
Background
The cluster of differentiation 4 receptor (CD4) is a 55kDa type I integral membrane glycoprotein which plays a substantial role during adaptive immune responses. In T-cells, CD4 mediates maturation, stabilizes T-cell receptor interactions with peptide-major histocompatibility complex class II (MHCII) complexes on antigen presenting cells, and mediates intracellular T-cell signalling.2 In addition to T-cells, CD4 has also been shown to be expressed on monocytes, monocyte-derived macrophages, Langerhans cells, B lymphocytes, dendritic cells, eosinophils, megakaryocytes and mast cells. The role of CD4 during immune function can also be diverted by the human immunodeficiency virus type 1 (HIV-1) envelope glycoprotein gp120 as the viral receptor utilizes CD4 as the primary receptor as well as the co-receptor CCR5/CXCR4 during the entry process.
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