SKU: 97247471769

Histone H4 (Lactyl K8) Recombinant Rabbit mAb (S-3243-36)

Sale price$90.00 Regular price$100.00
Save 10%

Pay in installments of $25.00 with ShopPay, AfterPay and Klarna

Shipping Estimate
USA
  • USA
  • CAN

Ships within 48 hours · Estimated delivery Aug 22 - Aug 27

Promo Codes Available:

For Your Every Summer RSVP, with Code: SUMMER15

Description

Histone H4 (Lactyl K8) Recombinant Rabbit mAb (S-3243-36)Product Specification Host Rabbit Antigen Histone H4 (Lactyl K8) Synonyms H4K8la Immunogen Synthetic Peptide Location Nucleus Accession P62805 Clone Number S 3243 36 Antibody Type Recombinant mAb Isotype IgG Application WB, IHC P, ICC Reactivity Hu, Ms, Rt Positive Sample HeLa treated with 100 mM Lactate sodium for 24 hours, NIH 3T3 treated with 100 mM Lactate sodium for 24 hours Purification Protein A Concentration 0. 5 mg ml Conjugation Unconjugated

Product Specification


Host Rabbit
Antigen Histone H4 (Lactyl K8)
Synonyms H4K8la
Immunogen Synthetic Peptide
Location Nucleus
Accession P62805
Clone Number S-3243-36
Antibody Type Recombinant mAb
Isotype IgG
Application WB, IHC-P, ICC
Reactivity Hu, Ms, Rt
Positive Sample HeLa treated with 100 mM Lactate sodium for 24 hours, NIH/3T3 treated with 100 mM Lactate sodium for 24 hours
Purification Protein A
Concentration 0.5 mg/ml
Conjugation Unconjugated
Physical Appearance Liquid
Storage Buffer

PBS, 40% Glycerol, 0.05% BSA, 0.03% Proclin 300

Stability & Storage

12 months from date of receipt / reconstitution, -20 °C as supplied

Dilution


application dilution species
WB 1:1000-1:2000 Hu, Ms
IHC-P 1:500 Hu, Ms, Rt
ICC 1:500 Hu

Background

Histone H4 (Lactyl K8), abbreviated as H4K8la, is a novel epigenetic modification involving the covalent attachment of a lactyl group to the 8th lysine residue of the histone H4 tail, serving as a direct molecular link between cellular glycolysis and gene transcriptional regulation. Discovered as part of the broader "histone lactylation" landscape, this mark is dynamically induced by high intracellular lactate levels, often resulting from hypoxia, intense exercise, or the Warburg effect in cancer cells. Functionally, H4K8la is strongly associated with the activation of specific gene programs; for instance, in macrophages, it accumulates during the late phase of polarization to promote the expression of reparative (M2-like) genes, thereby facilitating tissue repair and resolving inflammation, while in tumor microenvironments, it can drive the expression of oncogenes or factors supporting immune evasion. Mechanistically, the presence of the lactyl group at K8 alters chromatin structure and recruits specific "reader" proteins to enhance transcriptional elongation or initiation, distinguishing its regulatory role from the more constitutive H4K8 acetylation and highlighting its importance as a metabolic checkpoint in immunity, cancer progression, and developmental biology.

Shipping Notes
  • Free Standard Shipping on $100+ Orders to the USA.
  • Except Preorder products are shipped in 48 hours.
  • Delivery to the USA:
  1. Standard Shipping : 3-10 business days
  • If time is of the essence, please consider selecting expedited delivery for faster service.
Exchange/Return Notes
  • We offer a 30-day return/exchange service after receiving.
  • Final sale items are not eligible for returns or exchanges.
  • To process your return/exchange, please contact us at [email protected]
  • Please click here for more details>>> Return & Exchange Policy
SKU: 97247471769

Discover Niche Categories That Outsell

Top-Converting Item to Boost Your Average Order

4.5 ★★★★★
Based on 11 reviews
Sort
Highest Rating
Newest First
Oldest First
Product Reviews
D
Verified Purchase
Diana Crockett
Cuba, US
★★★★★ 5
The casa is wonderfully made and the keyboard is perfect
Color: Yellow
I love it , it works so well
WAS THIS REVIEW HELPFUL?YesReportShare
Reviewed in the United States on May 9, 2026
T
Verified Purchase
Tammy| Autism Momma
Bozeman, US
★★★★★ 5
Very sparkly!
Color: Pink
My iPad fits perfectly with only a small issue that it pops out in the corners easily if not careful. I am a gently user anyway so that’s a non issue for me. It’s easy to keep clean, the keyboard and mouse work flawlessly and were easy to connect.
WAS THIS REVIEW HELPFUL?YesReportShare
Reviewed in the United States on March 25, 2026
P
Verified Purchase
Pawlished LivingWith Stuart
Lake Worth, US
★★★★★ 5
Bling Bling
Color: Blue
I’m absolutely loving this iPad case with the wireless keyboard and mouse! The first thing that caught my eye was the gorgeous glittery blue color — it looks so stylish and unique without being over the top. The case feels sturdy and protective while still being lightweight and easy to carry. The keyboard connects quickly and types smoothly, making it perfect for work, school, or just browsing online. The wireless mouse is a great bonus and makes using the iPad feel much more like a laptop. I also love that the stand holds the iPad at a comfortable viewing angle for typing or watching videos. Everything charges easily, setup was simple, and the battery life has been great so far. Overall, this set completely upgraded my iPad experience and looks beautiful at the same time. Definitely recommend if you want something functional, protective, and cute
WAS THIS REVIEW HELPFUL?YesReportShare
Reviewed in the United States on May 23, 2026
P
Verified Purchase
Pricilla Piedra
Birmingham, US
★★★★★ 5
Just pay for it !
Color: Yellow, Color: Yellow
I love it! It’s super cute and cool! Love that it can light up the keyboard different colors. The keyboard and mouse have no issues with connection. It’s Sturdy and it’s def worth it!
WAS THIS REVIEW HELPFUL?YesReportShare
Reviewed in the United States on March 23, 2026
N
Verified Purchase
Nicole
San Leandro, US
★★★★★ 5
Exactly as advertised, works great!
Color: Green
Fits new iPad perfectly, relatively easy to get in & out of holder. Keyboard is easy to use and satisfyingly clicky. Mouse and keyboard synced up with the iPad immediately, no issues. Sparkly color is Kermit-green and exactly what I wanted.
WAS THIS REVIEW HELPFUL?YesReportShare
Reviewed in the United States on January 25, 2026

recommand products