SKU: 1465286056

Biotin Mouse Anti-Human CD170 (Siglec-5) Antibody (S-4097)

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Description

Biotin Mouse Anti-Human CD170 (Siglec-5) Antibody (S-4097)Product Specification Host Mouse Antigen CD170 (Siglec 5) Synonyms Sialic acid binding Ig like lectin 5; CD33 antigen like 2; Obesity binding protein 2 (OB BP2; OB binding protein 2); SIGLEC5; CD33L2; OBBP2 Location Membrane Accession O15389 Clone Number S 4097 Antibody Type Mouse mAb Isotype IgG1,k Application FCM Reactivity Hu Positive Sample Human Peripheral Blood cells Purification Protein G Concentration 0. 2 mg ml Conjugation Biotin Physical

Product Specification


Host Mouse
Antigen CD170 (Siglec-5)
Synonyms Sialic acid-binding Ig-like lectin 5; CD33 antigen-like 2; Obesity-binding protein 2 (OB-BP2; OB-binding protein 2); SIGLEC5; CD33L2; OBBP2
Location Membrane
Accession O15389
Clone Number S-4097
Antibody Type Mouse mAb
Isotype IgG1,k
Application FCM
Reactivity Hu
Positive Sample Human Peripheral Blood cells
Purification Protein G
Concentration 0.2 mg/ml
Conjugation Biotin
Physical Appearance Liquid
Storage Buffer

PBS pH7.4, 0.03% Proclin 300

Stability & Storage

12 months from date of receipt / reconstitution, 2 to 8 °C as supplied

Dilution


application dilution species
FCM 5μl per million cells in 100μl volume Hu

Background

CD170 protein, also known as sialic acid-binding immunoglobulin-like lectin-5 (Siglec-5), is a type I transmembrane inhibitory receptor primarily expressed on myeloid cells (such as monocytes, macrophages, and neutrophils) and some B cells. It belongs to the immunoglobulin superfamily and the Siglec family. Its extracellular region contains an immunoglobulin-like domain that specifically recognizes and binds to sialylated glycans (commonly found on host cell surfaces), while its intracellular region contains an immunoreceptor tyrosine-based inhibitory motif (ITIM). Upon binding to sialylated self-ligands, the ITIM domain of CD170 becomes phosphorylated, recruiting and activating SH2 domain-containing protein tyrosine phosphatases (e.g., SHP-1/SHP-2), thereby transmitting potent inhibitory signals that negatively regulate the activation of myeloid cells, the production of inflammatory cytokines, and phagocytic functions. This mechanism plays a critical role in maintaining immune homeostasis and preventing excessive inflammatory responses against self-tissues. In pathological conditions, certain pathogens or tumor cells can evade immune surveillance by engaging CD170 through "molecular mimicry" or "decoy" mechanisms using surface sialylated glycans, thereby promoting persistent infection or tumor progression. Thus, CD170 is not only a key regulator of immune self-tolerance but also a potential target for infection immunotherapy and cancer immunotherapy. Modulating its function—for example, using monoclonal antibodies for blockade or agonism—may offer novel therapeutic strategies for autoimmune diseases, chronic inflammation, and cancer.

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SKU: 1465286056

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4.2 ★★★★★
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Verified Purchase
Dani
Houston, US
★★★★★ 3
real good
Format: Kindle
This was a solid read for the ABO universe. The characters are great. The smut scenes were well written. And the town is so cute I want to go there. It didn’t have much character development it just felt like I was getting to the characters as they were getting to know each other.
WAS THIS REVIEW HELPFUL?YesReportShare
Reviewed in the United States on April 27, 2025
T
Tstar
Charlottesville, US
★★★★★ 5
So sweet
Format: Kindle
It’s so unexpectedly sweet that it sneaks up on you. Each character is so unique and charming. I love the openness and honesty among their pack. It really blows me away how wonderful this omegaverse trope plays out. I received a free copy of this book and am voluntarily leaving a review.
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Reviewed in the United States on March 21, 2026
Q
Verified Purchase
Queen of Anxiety
Alexandria, US
★★★★★ 2
Needs editing
Format: Kindle
Cute storyline and promising characters, but the lack of editing is painful to read. I would love to read an edited version.
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Reviewed in the United States on April 10, 2025
R
Verified Purchase
Ruth Ann Burt
San Leandro, US
★★★★★ 5
Great book
Format: Kindle
I absolutely feel in love with all 4 characters!!! The bedroom scenes were 🌋🌡🔥🔥🔥. I couldn't put this book down!!! I'm hooked for the whole series Book 2 here I come!!!!! Its a fun easy book and story to read!!
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Reviewed in the United States on October 4, 2024
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Verified Purchase
Danyelle
Pawtucket, US
★★★★★ 4
Fun with a late blooming omega
Format: Kindle
I like this book. The story is fun, cute, and sexy. There's just a little drama, some excellent, steamy scenes, and a fairly good relationship building storyline. I especially like how all the main characters are a bit older than the usual 20 somethings I tend to see in this kind of book. Having said that, I wish there were more descriptions of the places, as well as the food in the fancy restaurant. I enjoyed the cocktails at the club, so I missed that kind of detail when Gray took Madison on a dinner date. I also wish there had been more interaction between Lucas and Madison, and Lucas and Rian. It felt a bit lopsided, with a focus on Rian, Madison, and Gray. I wish it had been proofread - there are a lot of typos, but nothing too distracting.
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Reviewed in the United States on September 12, 2022

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