SKU: 21184259108

KCNQ2 Recombinant Rabbit mAb (S-3465-49)

Sale price$90.00 Regular price$100.00
Save 10%

Pay in installments of $25.00 with ShopPay, AfterPay and Klarna

Shipping Estimate
USA
  • USA
  • CAN

Ships within 48 hours · Estimated delivery Aug 23 - Aug 28

Promo Codes Available:

For Your Every Summer RSVP, with Code: SUMMER15

Description

KCNQ2 Recombinant Rabbit mAb (S-3465-49)Product Specification Host Rabbit Antigen KCNQ2 Synonyms Potassium voltage gated channel subfamily KQT member 2; KQT like 2; Neuroblastoma specific potassium channel subunit alpha KvLQT2; Voltage gated potassium channel subunit Kv7. 2 Immunogen Synthetic Peptide Location Cell membrane Accession O43526 Clone Number S 3465 49 Antibody Type Recombinant mAb Isotype IgG Application WB Reactivity Hu, Ms, Rt Positive Sample mouse brain, rat brain

Product Specification


Host Rabbit
Antigen KCNQ2
Synonyms Potassium voltage-gated channel subfamily KQT member 2; KQT-like 2; Neuroblastoma-specific potassium channel subunit alpha KvLQT2; Voltage-gated potassium channel subunit Kv7.2
Immunogen Synthetic Peptide
Location Cell membrane
Accession O43526
Clone Number S-3465-49
Antibody Type Recombinant mAb
Isotype IgG
Application WB
Reactivity Hu, Ms, Rt
Positive Sample mouse brain, rat brain
Purification Protein A
Concentration 2 mg/ml
Conjugation Unconjugated
Physical Appearance Liquid
Storage Buffer

PBS, 40% Glycerol, 0.05% BSA, 0.03% Proclin 300

Stability & Storage

12 months from date of receipt / reconstitution, -20 °C as supplied

Dilution


application dilution species
WB 1:1000 Hu, Ms, Rt

Background

The KCNQ2 protein is a voltage-gated potassium channel α-subunit, encoded by the KCNQ2 gene, that plays a critical role in regulating neuronal excitability throughout the central nervous system. Predominantly expressed in the brain, KCNQ2 primarily forms heterotetrameric complexes with KCNQ3 subunits to constitute the M-current (IKM), a slowly activating, non-inactivating potassium current that acts as a crucial brake on repetitive neuronal firing by stabilizing the resting membrane potential and preventing excessive depolarization. Functionally, this current is activated at subthreshold membrane potentials and is essential for controlling action potential threshold, firing frequency, and burst accommodation in neurons. Clinically, mutations in KCNQ2 are associated with a spectrum of epileptic disorders, ranging from benign familial neonatal epilepsy (BFNE) to severe developmental and epileptic encephalopathies (DEE) characterized by refractory seizures, intellectual disability, and neurodevelopmental impairment. The KCNQ2 channel serves as the primary pharmacological target for retigabine (ezogabine), an antiepileptic drug that activates the channel by inducing a conformational shift favoring the open state, thereby enhancing the M-current and reducing neuronal hyperexcitability. Structurally, KCNQ2 contains six transmembrane domains (S1-S6), with the S4 segment functioning as the voltage sensor and the S5-S6 loop forming the channel pore, while intracellular domains mediate subunit assembly, trafficking, and calmodulin-dependent regulation of channel gating kinetics.

Shipping Notes
  • Free Standard Shipping on $100+ Orders to the USA.
  • Except Preorder products are shipped in 48 hours.
  • Delivery to the USA:
  1. Standard Shipping : 3-10 business days
  • If time is of the essence, please consider selecting expedited delivery for faster service.
Exchange/Return Notes
  • We offer a 30-day return/exchange service after receiving.
  • Final sale items are not eligible for returns or exchanges.
  • To process your return/exchange, please contact us at [email protected]
  • Please click here for more details>>> Return & Exchange Policy
SKU: 21184259108

Discover Niche Categories That Outsell

Top-Converting Item to Boost Your Average Order

4.2 ★★★★★
Based on 12 reviews
Sort
Highest Rating
Newest First
Oldest First
Product Reviews
P
Verified Purchase
Paubla Maya
Lowell, US
★★★★★ 5
Incredible Value - Soft, Stays in Place, and Military Son Approved!
Size: California King, Size: California King
I purchased this mattress topper for under $27 and I'm so impressed that I'm planning to buy another one! Easy Installation & Perfect Fit: This topper was incredibly easy to put on, and it fits my California King mattress perfectly. The 18-inch deep pockets ensure it stays in place - I can move around on the bed and it doesn't shift at all. Comfort: The topper is wonderfully soft and has made a noticeable difference in our sleep quality. My husband absolutely loves it, and we both wake up feeling more rested. The Ultimate Test: My son recently came home after being deployed for a year. He slept on our bed for hours and immediately commented on how soft and comfortable it was. That's saying something for someone who's been sleeping on military accommodations! He was so impressed that he's planning to buy one for his ship. Bottom Line: For the price, comfort, and quality, I recommend this 100%. It's hypoallergenic, stays in place, and has exceeded all our expectations. You can't go wrong with this purchase!
WAS THIS REVIEW HELPFUL?YesReportShare
Reviewed in the United States on November 5, 2025
P
Verified Purchase
Pat Onstott
Omaha, US
★★★★★ 5
Nice mattress Topper Pad
Size: Queen
Met my expectations and was just as advertised. Good fit; comfortable.
WAS THIS REVIEW HELPFUL?YesReportShare
Reviewed in the United States on April 20, 2026
C
Verified Purchase
Camila
Bozeman, US
★★★★★ 5
Incredible
Size: Twin
This product exceeded my expectations. The quality is amazing, it works perfectly, and it was definitely worth the price. I’ve been using it for a while now and I’m really satisfied with the results. I would highly recommend it to anyone looking for something reliable and well made.”
WAS THIS REVIEW HELPFUL?YesReportShare
Reviewed in the United States on May 23, 2026
E
Verified Purchase
E Henriksen
Massapequa, US
★★★★★ 4
Mattress protector
Size: Twin
Arrived quickly. No factory odor. Was "scrunchy" out of the package, but fit snuggly around the twin mattress and doesn't make any annoying noise. Basic protective mattress topper. Water proof, but breathable, no condensation under the sheets. Disappointed there wasn't more "fluff", but does the job of protecting my mattress from coffee spills and natural body sweat in between weekly washing. I've had it a while, and it seems to be holding up with monthly washing and drying.
WAS THIS REVIEW HELPFUL?YesReportShare
Reviewed in the United States on April 23, 2026
S
Verified Purchase
STEPHANIE CATANZARO
Pawtucket, US
★★★★★ 5
Mattress pad
Size: Queen
This mattress pad is comfortable it makes a difference when it on the mattress. It’s makes the bed feel softer instead of hard.
WAS THIS REVIEW HELPFUL?YesReportShare
Reviewed in the United States on May 27, 2026

recommand products