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Description
Canine CRP, His tagProduct Specification Species Canine Synonyms Pentraxin Accession T2KEN6 Amino Acid Sequence Protein sequence(T2KEN6, Gln20 Ser223, with C 10*His) QIDLDEKAFVFPRESENSYVILFPQLQKPMKAFTVCLQVYTDLTRPHSLFSYATKSQSNEILLFKERPGLFSVSVGGSDAFINFPQKFYAPQHFCVTWESVTGLTELWVDGKPMVRASLRRGYTVGSGASIVLGQEQDSFGGGFDKNQSLVGDIEDVNMWDFVLSPSQILTLYTTRALSPNVLNWRNLRYETRGEVFLKKELWSGGGGSHHHHHHHHHH Expression System HEK293 Molecular Weight Theoretical: 24. 8kDa Actual: 25, 29kDa Purity
Product Specification
| Species | Canine |
| Synonyms | Pentraxin |
| Accession | T2KEN6 |
| Amino Acid Sequence | Protein sequence(T2KEN6, ·Gln20-Ser223, with C-10*His) QIDLDEKAFVFPRESENSYVILFPQLQKPMKAFTVCLQVYTDLTRPHSLFSYATKSQSNEILLFKERPGLFSVSVGGSDAFINFPQKFYAPQHFCVTWESVTGLTELWVDGKPMVRASLRRGYTVGSGASIVLGQEQDSFGGGFDKNQSLVGDIEDVNMWDFVLSPSQILTLYTTRALSPNVLNWRNLRYETRGEVFLKKELWSGGGGSHHHHHHHHHH |
| Expression System | HEK293 |
| Molecular Weight | Theoretical:24.8kDa Actual:25, 29kDa |
| Purity | ＞95% by SDS-PAGE |
| Endotoxin | <1EU/μg |
| Conjugation | Unconjugated |
| Tag | His Tag |
| Physical Appearance | Lyophilized Powder |
| Storage Buffer | Lyophilized from a 0.2 μm filtered solution of 0.2M PBS, pH7.4. |
| Reconstitution | Reconstitute no more than 1 mg/mL according to the size in deionized water after rapid centrifugation. |
| Stability & Storage |
12 months from date of receipt, -20 to -70 °C as supplied. 6 months. -20 to -70 °C under sterile conditions after reconstitution. 1 week, 2 to 8 °C under sterile conditions after reconstitution. Please avoid repeated freeze-thaw cycles. |
Background
C-reactive protein (CRP) is an annular (ring-shaped) pentameric protein found in blood plasma, whose circulating concentrations rise in response to inflammation. It is an acute-phase protein of hepatic origin that increases following interleukin-6 secretion by macrophages and T cells. Its physiological role is to bind to lysophosphatidylcholine expressed on the surface of dead or dying cells (and some types of bacteria) in order to activate the complement system via C1q. CRP is used mainly as an inflammation marker. Apart from liver failure, there are few known factors that interfere with CRP production. Interferon alpha inhibits CRP production from liver cells which may explain the relatively low levels of CRP found during viral infections compared to bacterial infections.
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