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Description
APC Mouse Anti-Human CD59 Antibody (S-R567)Product Specification Host Mouse Antigen CD59 Synonyms CD59 glycoprotein; 1F5 antigen; 20 kDa homologous restriction factor (HRF 20; HRF20); MAC inhibitory protein (MAC IP); MEM43 antigen; Membrane attack complex inhibition factor (MACIF); Membrane inhibitor of reactive lysis (MIRL); Protectin; MIC11; MIN1; MIN2; MIN3; MSK21 Location Secreted, Cell membrane Accession P13987 Clone Number S R567 Antibody Type Mouse mAb Isotype IgG2a Application FCM
Product Specification
| Host | Mouse |
| Antigen | CD59 |
| Synonyms | CD59 glycoprotein; 1F5 antigen; 20 kDa homologous restriction factor (HRF-20; HRF20); MAC-inhibitory protein (MAC-IP); MEM43 antigen; Membrane attack complex inhibition factor (MACIF); Membrane inhibitor of reactive lysis (MIRL); Protectin; MIC11; MIN1; MIN2; MIN3; MSK21 |
| Location | Secreted, Cell membrane |
| Accession | P13987 |
| Clone Number | S-R567 |
| Antibody Type | Mouse mAb |
| Isotype | IgG2a |
| Application | FCM |
| Reactivity | Hu |
| Positive Sample | human peripheral blood cells |
| Purification | Protein A |
| Concentration | 0.2 mg/ml |
| Conjugation | APC |
| Physical Appearance | Liquid |
| Storage Buffer | PBS, 1% BSA, 0.3% Proclin 300 |
| Stability & Storage | 12 months from date of receipt / reconstitution, 2 to 8 °C as supplied. |
Dilution
| application | dilution | species |
| FCM | 5μl per million cells in 100μl volume | Hu |
Background
CD59, also known as membrane inhibitor of reactive lysis (MIRL) or protectin, is a glycosylphosphatidylinositol (GPI)-anchored membrane protein that plays a crucial role in regulating the complement system, an essential part of the innate immune response. It is widely expressed on various human cells and tissues, including erythrocytes, leukocytes, fibroblasts, and epithelial cells. The primary function of CD59 is to inhibit the formation of the membrane attack complex (MAC), thereby preventing complement-mediated cell lysis. This protective mechanism is vital for maintaining cell integrity and preventing excessive immune-mediated damage.
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Exchange/Return Notes
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