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Description
PAX6 Recombinant Rabbit mAb (SDT-1258-145)Product Specification Host Rabbit Antigen PAX6 Synonyms Paired box protein Pax 6; Aniridia type II protein; Oculorhombin; AN2 Immunogen Synthetic Peptide Location Nucleus Accession P26367 Clone Number SDT 1258 145 Antibody Type Recombinant mAb Isotype IgG Application WB, IHC P Reactivity Hu, Ms, Rt Positive Sample 293T, Neuro 2a Purification Protein A Concentration 0. 5 mg ml Conjugation Unconjugated Physical Appearance Liquid Storage Buffer PBS, 40%
Product Specification
| Host | Rabbit |
| Antigen | PAX6 |
| Synonyms | Paired box protein Pax-6; Aniridia type II protein; Oculorhombin; AN2 |
| Immunogen | Synthetic Peptide |
| Location | Nucleus |
| Accession | P26367 |
| Clone Number | SDT-1258-145 |
| Antibody Type | Recombinant mAb |
| Isotype | IgG |
| Application | WB, IHC-P |
| Reactivity | Hu, Ms, Rt |
| Positive Sample | 293T, Neuro-2a |
| Purification | Protein A |
| Concentration | 0.5 mg/ml |
| Conjugation | Unconjugated |
| Physical Appearance | Liquid |
| Storage Buffer | PBS, 40% Glycerol, 0.05% BSA, 0.03% Proclin 300 |
| Stability & Storage | 12 months from date of receipt / reconstitution, -20 °C as supplied |
Dilution
| application | dilution | species |
| WB | 1:1000 | Hu, Ms |
| IHC-P | 1:1000 | Hu, Ms, Rt |
Background
PAX6, also known as Paired Box 6, is a highly conserved transcription factor that plays a crucial role in the development of multiple organs and tissues, particularly the eyes, brain, and pancreas. It is involved in the regulation of gene expression during embryonic development and is essential for the formation of the eyes, central nervous system, and endocrine pancreas. Mutations in the PAX6 gene can lead to a variety of conditions, including aniridia (absence of the iris), microphthalmia (small eyes), and coloboma (gaps in eye structures). Additionally, PAX6 is implicated in the development of the olfactory bulb and the regulation of neuronal migration and cell proliferation. Its importance is further highlighted by its role in maintaining the normal function of certain cells after birth.
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