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Description
TIMP1 Fc Chimera Protein, HumanProduct Specification Species Human Synonyms TIMP1, CLGI, TIMP Accession P01033 Amino Acid Sequence Cys24 Ala207, with N terminal Human IgG1 Fc
Product Specification
| Species | Human |
| Synonyms | TIMP1, CLGI, TIMP |
| Accession | P01033 |
| Amino Acid Sequence | Cys24-Ala207, with N-terminal Human IgG1 Fc DKTHTSPPSPAPELLGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEVHNAKTKPREEQYNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKALPAPIEKTISKAKGQPREPQVYTLPPSRDELTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSPGKGGGSGGGSGGGSGGGSGGGSDDDDKCTCVPPHPQTAFCNSDLVIRAKFVGTPEVNQTTLYQRYEIKMTKMYKGFQALGDAADIRFVYTPAMESVCGYFHRSHNRSEEFLIAGKLQDGLLHITTCSFVAPWNSLSLAQRRGFTKTYTVGCEECTVFPCLSIPCKLQSGTHCLWTDQLLQGSEKGFQSRHLACLPREPGLCTWQSLRSQIA |
| Expression System | HEK293 |
| Molecular Weight | 55-65kDa |
| Purity | >95% by SDS-PAGE |
| Endotoxin | <0.1EU/μg |
| Conjugation | Unconjugated |
| Physical Appearance | Lyophilized Powder |
| Storage Buffer | PBS, pH7.4 |
| Reconstitution | Reconstitute at 0.1-1 mg/ml according to the size in ultrapure water after rapid centrifugation. |
| Stability & Storage | · 12 months from date of receipt, lyophilized powder stored at -20 to -80℃. · 3 months, -20 to -80℃ under sterile conditions after reconstitution. · 1 week, 2 to 8℃ under sterile conditions after reconstitution. · Please avoid repeated freeze-thaw cycles. |
| Reference |
1、Hornebeck W. (2004) Down-regulation of tissue inhibitor of matrix metalloprotease-1 (TIMP-1) in aged human skin contributes to matrix degradation and impaired cell growth and survival. Pathol Biol. 51(10): 569-573. 2、Soini Y. et al. (2001) Expression of MMP2, MMP9, MT1-MMP, TIMP-1, and TIMP2 mRNA in valvular lesions of the heart. J Pathol. 194(2): 225-231. |
Background
TIMP metallopeptidase inhibitor 1 is also known as TIMP1, a tissue inhibitor of metalloproteinases, is a glycoprotein that is expressed from the several tissues of organisms. TIMP1 is a glycoprotein with a molecular mass of 28 kDa produced by a wide range of cell types. Tissue inhibitor matrix metalloproteinase 1 (TIMP1), which belongs to TIMP gene family, is a natural inhibitor of the matrix metalloproteinases (MMPs). Tissue inhibitor of metalloproteinases 1 (TIMP1) was the secreted factor with the strongest male-biased expression in patient-derived pancreatic tumors. Male-specific up-regulation of systemic TIMP1 was demonstrated in PC mouse models and patients. Using TIMP1-competent and TIMP1-deficient PC mouse models, we established a causal role of TIMP1 in determining shortened survival and increased liver metastasis in males.
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4.8 ★★★★★
Based on 26 reviews
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Product Reviews
★★★★★ 5
Great idea
These are a good idea, I use frozen pumpkin and frozen blueberries in a cup, then put it in the corn, for my dog to have, while I'm at work.
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Reviewed in the United States on March 23, 2026
★★★★★ 3
made of STONE
i think the concept is great but the execution of the product is lacking. This is not made of rubber, there is no dog I can imagine chewing this thing. It is basically a STONE and rock hard and has absolutely zero give. She tried to chew it for one second and immediately stopped - the only thing the dog can do is lick so that aspect was disappointing. However, the toy works, keeps her attention and she loves the treat so all in all - not bad.
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Reviewed in the United States on October 14, 2025
★★★★★ 4
My dogs are heavy chewers
These are very hard and indestructible. The only thing, im afraid my pups will break their teeth. They are houses on a hard wood floor.
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Reviewed in the United States on November 30, 2025
★★★★★ 5
My couch is safe!
Perfect for my lab mix, and my pointer mix was jealous so I immediately bought a second after they both wanted it. Keeps them both busy for well over 30 minutes.
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Reviewed in the United States on March 8, 2026
★★★★★ 5
Great treat holder!
Our new favorite!! We’d been long time long users but this will forever replace them. Sturdy, easy to clean, convenient cups, multiple fun treat compartments. They are also bright enough to find in the yard if one “runs” out the house. And they are easy for the kids to hold. Must have for a Pitt bull family
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Reviewed in the United States on December 16, 2025
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