Pay in installments of $64.00 with
,
and
Shipping Estimate
USA
- USA
- CAN
- USA
- CAN
Ships within 48 hours · Estimated delivery Aug 22 - Aug 27
Promo Codes Available:
For Your Every Summer RSVP, with Code: SUMMER15
Description
SLAMF7/CRACC/CD319 His Tag Protein, CynomolgusProduct Specification Species Cynomolgus Synonyms SLAMF7, CD319, CS1, CRACC, 19A, FOAP 12 Accession XP_005541294. 2 Amino Acid Sequence Ser23 Met226, with C terminal 10*His SGSVKELVGSIGGAVTFPLKSEVKQVDSIVWTFNTTTLVTIQPEGGPMIVTQNRNKERVDFPDGGYSLKLSKLKKNDSGIYNVEIYSSSLQDPFTRKYVLRVYEHLSKPKVTMGLQSNKNGTCVTNLTCHMEHGEEDVIYTWKALGQAVNESHNGSILPISWRWGESDMTFICTVRNPVSSNSSSPILARKLCEGAADDSDSSMGGGSGGGSHHHHHHHHHH Expression System HEK293 Molecular Weight 35 45kDa Purity
Product Specification
| Species | Cynomolgus |
| Synonyms | SLAMF7, CD319, CS1, CRACC, 19A, FOAP-12 |
| Accession | XP_005541294.2 |
| Amino Acid Sequence | Ser23-Met226, with C-terminal 10*His SGSVKELVGSIGGAVTFPLKSEVKQVDSIVWTFNTTTLVTIQPEGGPMIVTQNRNKERVDFPDGGYSLKLSKLKKNDSGIYNVEIYSSSLQDPFTRKYVLRVYEHLSKPKVTMGLQSNKNGTCVTNLTCHMEHGEEDVIYTWKALGQAVNESHNGSILPISWRWGESDMTFICTVRNPVSSNSSSPILARKLCEGAADDSDSSMGGGSGGGSHHHHHHHHHH |
| Expression System | HEK293 |
| Molecular Weight | 35-45kDa |
| Purity | >95% by SDS-PAGE |
| Endotoxin | <0.1EU/μg |
| Conjugation | Unconjugated |
| Tag | His Tag |
| Physical Appearance | Lyophilized Powder |
| Storage Buffer | PBS, pH7.4 |
| Reconstitution | Reconstitute at 0.1-1 mg/ml according to the size in ultrapure water after rapid centrifugation. |
| Stability & Storage | · 12 months from date of receipt, lyophilized powder stored at -20 to -80℃. · 3 months, -20 to -80℃ under sterile conditions after reconstitution. · 1 week, 2 to 8℃ under sterile conditions after reconstitution. · Please avoid repeated freeze-thaw cycles. |
| Reference |
1、Lee J K. et al. (2004) Molecular and functional characterization of a CS1 (CRACC) splice variant expressed in human NK cells that does not contain immunoreceptor tyrosine-based switch motifs. Eur J Immunol. 34(10): 2791-2799. 2、Tassi I. et al. (2005) The cytotoxicity receptor CRACC (CS-1) recruits EAT-2 and activates the PI3K and phospholipase Cgamma signaling pathways in human NK cells. J Immunol. 175(12): 7996-8002. 3、Lee J K. et al. (2007) CS1 (CRACC, CD319) induces proliferation and autocrine cytokine expression on human B lymphocytes. J Immunol. 179(7): 4672-4678. 4、Cruz-Munoz M E. et al. (2009) Influence of CRACC, a SLAM family receptor coupled to the adaptor EAT-2, on natural killer cell function. Nat Immunol. 10(3): 297-305. |
Background
SLAM family member 7 (SLAMF7) is also known as CD2-like receptor-activating cytotoxic cells (CRACC), Membrane protein FOAP-12, CD antigen CD319, Novel Ly9, Protein 19A, which is a single-pass type I membrane protein and a member of the CD2 family of cell surface receptors. Mature mouse CRACC consists of a 202 amino acid (aa) extracellular domain (ECD) with one Ig-like V-set domain and one Ig-like C2-set domain, a 21 aa transmembrane segment, and an 88 aa cytoplasmic domain with two immunoreceptor tyrosine-based switch motifs ITSMs. SLAM receptors triggered by homo- or heterotypic cell-cell interactions are modulating the activation and differentiation of a wide variety of immune cells and thus are involved in the regulation and interconnection of both innate and adaptive immune response. Activities are controlled by presence or absence of small cytoplasmic adapter proteins, SH2D1A/SAP and/or SH2D1B/EAT-2. Mediates natural killer (NK) cell activation through a SH2D1A-independent extracellular signal-regulated ERK-mediated pathway. Positively regulates NK cell functions by a mechanism dependent on the adapter SH2D1B. In addition to heterotypic NK cells-target cells interactions also homotypic interactions between NK cells may contribute to activation. However, in the absence of SH2D1B, inhibits NK cell function.
Shipping Notes
- Free Standard Shipping on $100+ Orders to the USA.
- Except Preorder products are shipped in 48 hours.
- Delivery to the USA:
- Standard Shipping : 3-10 business days
- If time is of the essence, please consider selecting expedited delivery for faster service.
Exchange/Return Notes
- We offer a 30-day return/exchange service after receiving.
- Final sale items are not eligible for returns or exchanges.
- To process your return/exchange, please contact us at [email protected]
- Please click here for more details>>> Return & Exchange Policy
4.5 ★★★★★
Based on 19 reviews
Sort
Product Reviews
★★★★★ 4
Comfortable and soft
Color: Black, Size: Small
I purchased these in small. I have a 30-inch waist, and the small is loose on me. They are described as handmade, and to expect some variance, but there is a noticeable difference between individual items. Individually, they are well constructed, just inconsistent in size.
WAS THIS REVIEW HELPFUL?YesReportShare
Reviewed in the United States on April 30, 2026
★★★★★ 5
Just buy them
Color: Black,navy,burgundy,brown, Size: Small
Used to wear sliders all the time, figured i'd switch it up. These are super comfortable, probably the best material underwear I own. Great to just lounge around it or wear everyday. Fit is really good, I got a small and about 29-30" waist. Good bang for your buck too. I've washed them a handful of times and they hold up great, fit great and dont' shrink.
WAS THIS REVIEW HELPFUL?YesReportShare
Reviewed in the United States on May 7, 2026
★★★★★ 5
Good underwear. Husband likes them.
Color: Black, Size: Large
Husband wears XL and XL fit well. This is the second pack I got for him. They are decent quality, look and feel nice, not baggy yet not too tight anywhere. They are somewhat thin (but still supportive) and do not make him sweat more so he loves that. No problems washing (they didn’t shrink). Will continue to repurchase these.
WAS THIS REVIEW HELPFUL?YesReportShare
Reviewed in the United States on May 11, 2026
★★★★★ 5
Comfortable
Color: Black,navy,burgundy,brown, Size: Medium
I have had a lifetime of different briefs, some name brand, some generic.
I am 165 lbs, wear Medium, and these are closest to feeling commando of anything I’ve ever worn.
Comfortable, not too tight waist and legs, and yes silky touch yet not slinky.
Maybe not for support wear, but casual and cool comfort, the “Cat’s meow”.
I just came on to order some more
WAS THIS REVIEW HELPFUL?YesReportShare
Reviewed in the United States on April 30, 2026
★★★★★ 3
Great fabric - pouch too small!
Color: Black, Size: X-Large
First, the fabric used is wonderfully soft and comfortable. It;s the first thing noticed when package was opened. Strange, but the elastic waistband is about 1/2", very similar to a woman's style panty. But it's comfortable and easily acceptable.
The main problem is that the pouch that holds your "stuff" in place, is oddly and unnaturally small. Small enough where this average man's "stuff" tends to fall out of the pouch on one side or the other. I sleep in my underwear, and every time I did with these, I awoke with the front pouch off to the side and everything down there was hanging outside of the underwear.
They also seem to do well through a wash cycle. However, if the main reason for wearing underwear is to keep your stuff in place, these fail from the beginning.
I ordered another brand from overseas, and they had the exact same problems as these! I wonder if that's just how they make them outside of the USA.
The Bottom Line?
Uncle Steve Disapproved!
WAS THIS REVIEW HELPFUL?YesReportShare
Reviewed in the United States on October 30, 2025