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Description
CDS1 Recombinant Rabbit mAb (S-3671-30)Product Specification Host Rabbit Antigen CDS1 Synonyms Phosphatidate cytidylyltransferase 1; CDP DAG synthase 1; CDP DG synthase 1; CDP diacylglycerol synthase 1 (CDS 1); CDP diglyceride pyrophosphorylase 1; CDP diglyceride synthase 1; CTP: phosphatidate cytidylyltransferase 1; CDS Immunogen Synthetic Peptide Location Endoplasmic reticulum Accession Q92903 Clone Number S 3671 30 Antibody Type Recombinant mAb Isotype IgG Application WB, IHC P
Product Specification
| Host | Rabbit |
| Antigen | CDS1 |
| Synonyms | Phosphatidate cytidylyltransferase 1; CDP-DAG synthase 1; CDP-DG synthase 1; CDP-diacylglycerol synthase 1 (CDS 1); CDP-diglyceride pyrophosphorylase 1; CDP-diglyceride synthase 1; CTP:phosphatidate cytidylyltransferase 1; CDS |
| Immunogen | Synthetic Peptide |
| Location | Endoplasmic reticulum |
| Accession | Q92903 |
| Clone Number | S-3671-30 |
| Antibody Type | Recombinant mAb |
| Isotype | IgG |
| Application | WB, IHC-P |
| Reactivity | Hu, Ms, Rt |
| Positive Sample | SK-BR-3, A431, PC-3, RAW264.7 |
| Purification | Protein A |
| Concentration | 0.5 mg/ml |
| Conjugation | Unconjugated |
| Physical Appearance | Liquid |
| Storage Buffer | PBS, 40% Glycerol, 0.05% BSA, 0.03% Proclin 300 |
| Stability & Storage | 12 months from date of receipt / reconstitution, -20 °C as supplied |
Dilution
| application | dilution | species |
| WB | 1:1000-1:2000 | Hu, Ms |
| IHC-P | 1:1000 | Hu, Ms, Rt |
Background
CDP-diacylglycerol synthase 1 (CDS1), also known as CDP-DAG synthase 1, is a critical integral membrane enzyme primarily located in the endoplasmic reticulum that catalyzes the conversion of phosphatidic acid (PA) and cytidine triphosphate (CTP) into cytidine diphosphate-diacylglycerol (CDP-DAG), serving as the committed and rate-limiting step in the de novo biosynthesis of major phospholipids such as phosphatidylinositol (PI), phosphatidylglycerol (PG), and cardiolipin. As a central hub in lipid metabolism, CDS1 regulates the flux of PA toward phospholipid production rather than triglyceride synthesis or signaling pathways, thereby maintaining cellular membrane integrity, facilitating signal transduction cascades like the PI3K/Akt pathway, and supporting mitochondrial function through cardiolipin generation; its activity is tightly regulated by feedback inhibition from downstream products and transcriptional mechanisms, and dysregulation or mutations in the CDS1 gene have been implicated in severe metabolic disorders, including congenital lipodystrophy, insulin resistance, and altered susceptibility to viral infections due to compromised membrane architecture.
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Exchange/Return Notes
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