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Description
Prolactin R/PRLR His Tag Protein, HumanProduct Specification Species Human Synonyms Prolactin R, PRLR, PRL R Accession P16471 Amino Acid Sequence Gln25 Asp234, with C terminal 8*His QLPPGKPEIFKCRSPNKETFTCWWRPGTDGGLPTNYSLTYHREGETLMHECPDYITGGPNSCHFGKQYTSMWRTYIMMVNATNQMGSSFSDELYVDVTYIVQPDPPLELAVEVKQPEDRKPYLWIKWSPPTLIDLKTGWFTLLYEIRLKPEKAAEWEIHFAGQQTEFKILSLHPGQKYLVQVRCKPDHGYWSAWSPATFIQIPSDFTMNDGGGSHHHHHHHH Expression System HEK293 Molecular Weight 32 36kDa Purity >95% by SDS PAGE Endotoxin <0.
Product Specification
| Species | Human |
| Synonyms | Prolactin R, PRLR, PRL-R |
| Accession | P16471 |
| Amino Acid Sequence | Gln25-Asp234, with C-terminal 8*His QLPPGKPEIFKCRSPNKETFTCWWRPGTDGGLPTNYSLTYHREGETLMHECPDYITGGPNSCHFGKQYTSMWRTYIMMVNATNQMGSSFSDELYVDVTYIVQPDPPLELAVEVKQPEDRKPYLWIKWSPPTLIDLKTGWFTLLYEIRLKPEKAAEWEIHFAGQQTEFKILSLHPGQKYLVQVRCKPDHGYWSAWSPATFIQIPSDFTMNDGGGSHHHHHHHH |
| Expression System | HEK293 |
| Molecular Weight | 32-36kDa |
| Purity | >95% by SDS-PAGE |
| Endotoxin | <0.1EU/μg |
| Conjugation | Unconjugated |
| Tag | His Tag |
| Physical Appearance | Lyophilized Powder |
| Storage Buffer | PBS, pH7.4 |
| Reconstitution | Reconstitute at 0.1-1 mg/ml according to the size in ultrapure water after rapid centrifugation. |
| Stability & Storage | · 12 months from date of receipt, lyophilized powder stored at -20 to -80℃. · 3 months, -20 to -80℃ under sterile conditions after reconstitution. · 1 week, 2 to 8℃ under sterile conditions after reconstitution. · Please avoid repeated freeze-thaw cycles. |
| Reference | 1、Bole-Feysot C. et al. (1998) Prolactin (PRL) and its receptor: actions, signal transduction pathways and phenotypes observed in PRL receptor knockout mice. Endocr Rev. 19(3): 225-268. |
Background
Prolactin receptor (PRLR) is a single-pass transmembrane receptor belonging to the type I cytokine receptor superfamily, and contains two fibronectin type-III domains. Knockout prolactin receptor gene (PRL-R) mice are animal models for prolactinomas and PRL acts via autocrine/paracrine inhibiting lactotroph proliferation. Recently, variants of the PRL-R were identified in prolactinoma patients and their frequency was higher compared to individuals from the genomic database. As a transmembrane receptor, the prolactin receptor (PRL-R) interacts with prolactin. The PRL-R also binds and is activated by growth hormone (GH) and human placental lactogen (hPL). Moreover, The PRLR has been found to be essential for lobuloalveolar maturation of the mammary glands during pregnancy, as evidenced by the fact that PRLR knockout mice show severely impaired development of lobuloalveolar structures.
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Reviewed in the United States on May 9, 2026
★★★★★ 5
Good product!
Size: 6.76 Fl Oz (Pack of 3)
Good for your body and feet
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Reviewed in the United States on December 26, 2025
★★★★★ 5
Nivea cream
Size: 6.76 Fl Oz (Pack of 3)
I use this daily, very creamy and not greasy
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Reviewed in the United States on April 12, 2026
★★★★★ 4
Reliable age old formula
Size: 6.76 Fl Oz (Pack of 3)
I have used this formula for decades and it is reliable and consistent.
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Reviewed in the United States on January 7, 2025
★★★★★ 5
Dry Face needs moisture
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This cream was a lifesaver when my face was extremely dry. It’s rich but absorbs well, leaving my skin feeling deeply moisturized and smooth without feeling greasy. A little goes a long way, and it really helped restore my skin barrier.
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Reviewed in the United States on February 7, 2026