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Description
Her4 His Tag Protein, HumanProduct Specification Species Human Synonyms Her4, ERBB4, 4ICD, MGC138404, p180erbB4 Accession Q15303 Amino Acid Sequence Gln26 Pro651, with C terminal 10*His
Product Specification
| Species | Human |
| Synonyms | Her4, ERBB4, 4ICD, MGC138404, p180erbB4 |
| Accession | Q15303 |
| Amino Acid Sequence | Gln26-Pro651, with C-terminal 10*His QSVCAGTENKLSSLSDLEQQYRALRKYYENCEVVMGNLEITSIEHNRDLSFLRSVREVTGYVLVALNQFRYLPLENLRIIRGTKLYEDRYALAIFLNYRKDGNFGLQELGLKNLTEILNGGVYVDQNKFLCYADTIHWQDIVRNPWPSNLTLVSTNGSSGCGRCHKSCTGRCWGPTENHCQTLTRTVCAEQCDGRCYGPYVSDCCHRECAGGCSGPKDTDCFACMNFNDSGACVTQCPQTFVYNPTTFQLEHNFNAKYTYGAFCVKKCPHNFVVDSSSCVRACPSSKMEVEENGIKMCKPCTDICPKACDGIGTGSLMSAQTVDSSNIDKFINCTKINGNLIFLVTGIHGDPYNAIEAIDPEKLNVFRTVREITGFLNIQSWPPNMTDFSVFSNLVTIGGRVLYSGLSLLILKQQGITSLQFQSLKEISAGNIYITDNSNLCYYHTINWTTLFSTINQRIVIRDNRKAENCTAEGMVCNHLCSSDGCWGPGPDQCLSCRRFSRGRICIESCNLYDGEFREFENGSICVECDPQCEKMEDGLLTCHGPGPDNCTKCSHFKDGPNCVEKCPDGLQGANSFIFKYADPDRECHPCHPNCTQGCNGPTSHDCIYYPWTGHSTLPQHARTPGGGSGGGSHHHHHHHHHH |
| Expression System | HEK293 |
| Molecular Weight | 87-101kDa |
| Purity | >95% by SDS-PAGE |
| Endotoxin | <0.1EU/μg |
| Conjugation | Unconjugated |
| Tag | His Tag |
| Physical Appearance | Lyophilized Powder |
| Storage Buffer | PBS, pH7.4 |
| Reconstitution | Reconstitute at 0.1-1 mg/ml according to the size in ultrapure water after rapid centrifugation. |
| Stability & Storage | 12 months from date of receipt, -20 to -70 °C as supplied; 6 months, -20 to -70 °C under sterile conditions after reconstitution; 1 week, 2 to 8 °C under sterile conditions after reconstitution; Please avoid repeated freeze-thaw cycles. |
| Reference |
1、Segers V F M. et al. (2020) The role of ErbB4 in cancer. Cell Oncol. 43: 335-352. 2、Xu J. et al. (2018) ERBB4 promotes the proliferation of gastric cancer cells via the PI3K/Akt signaling pathway. Oncol Rep 39: 2892-2898. |
Background
HER4, also known as ErbB4, is a member of epidermal growth factor receptor (EGFR) or ErbB family. The HER4 gene is localized on chromosome 2q33.3–34. HER4 is necessary for normal development of body systems including heart, nervous system, and mammary gland. HER4 is commonly expressed in many human tissues, both adult and fetal. EGFR/ErbB1/HER1, ErbB2/HER2, ErbB3/HER3, and ErbB4/HER4 are members of this receptor tyrosine kinase family. HER4 is the only member of this family of receptors with growth inhibiting properties. HER4 can activate related genes in the nucleus when combined with epidermal growth factor (EGF), promoting cell division and proliferation. It is activated through ligand binding and activates MAPKs and PI3K/AKT pathways. Her4 promotes glycolysis, glutaminolysis, mitochondrial biogenesis & OXPHOS through c-Myc-dependent signaling axis in cancer. The Her4-mediated metabolic reprogramming may in part cooperate to promote tumorigenesis in certain cancers.
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4.6 ★★★★★
Based on 29 reviews
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Product Reviews
★★★★★ 5
Fun Brain stimulating puzzle toy
Color: Green
this is a Great Puzzle/brain toy for puppies! My Dog really enjoys interacting with it! It is well made and larger than most of the ones I saw.. sturdy stable and very good for puppies to use their brain to figure out how to get a treat!! recommend highly and price was fair and shipped very quickly
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Reviewed in the United States on April 23, 2026
★★★★★ 5
Definitely recommend this product
Color: Green
Very pleased with this item - it is very similar to the Outward Hound brand but less expensive. I chose this product which doesn’t have easily removable parts - they would be a chocking hazard. Overall it seems durable, engaging and chew resistant - as long as your dog is supervised
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Reviewed in the United States on June 7, 2026
★★★★★ 3
Needs improvement
Color: Green
The cups are deep enough and the bone has to have the circle to rotate before the bone can move. I had a hard time figuring it out and so has Our dog . There are 4 black rubber parts included but no instruction on what to do with them. After seeing the toy move across the floor, I figured out these needed to go on the bottom 4 corners. Cute, but needs improvement.
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Reviewed in the United States on May 8, 2026
★★★★★ 5
Great treat toy
Color: Green
Great toy for mind stimulation. Somes i feed her in this especially when i have to leave her at home for couple hrs. Best toy for beginners dogs who is new to these type of toys. Recommend. Our other dog husky mix still needs assistance on using it but she is getting there.
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Reviewed in the United States on May 5, 2026
★★★★★ 5
A fun interactive puzzle your dog will enjoy!
Color: Green
It's a fun interactive puzzle for your pet.
I have a mini cockapoo and he mastered finding the treats on the first try.
Then I made it more challenging for my dog and it took awhile for him to master it. My dog never got bored or gave in. He seemed to like the challenge of finding all his treats.
Fun and challenging puzzle!
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Reviewed in the United States on May 24, 2026