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Description
Human t-PA, His TagProduct Specification Species Human Accession P00750 Amino Acid Sequence IKGGLFADIASHPWQAAIFAKHRRSPGERFLCGGILISSCWILSAAHCFQERFPPHHLTVILGRTYRVVPGEEEQKFEVEKYIVHKEFDDDTYDNDIALLQLKSDSSRCAQESSVVRTVCLPPADLQLPDWTECELSGYGKHEALSPFYSERLKEAHVRLYPSSRCTSQHLLNRTVTDNMLCAGDTRSGGPQANLHDACQGDSGGPLVCLNDGRMTLVGIISWGLGCGQKDVPGVYTKVTNYLDWIRDNMRPGGGGSHHHHHHHHHH. Expression System HEK293 Molecular Weight 29. 8 kDa (reducing) Purity 95% by SDS PAGE Endotoxin <1EU g
Product Specification
| Species | Human |
| Accession | P00750 |
| Amino Acid Sequence | IKGGLFADIASHPWQAAIFAKHRRSPGERFLCGGILISSCWILSAAHCFQERFPPHHLTVILGRTYRVVPGEEEQKFEVEKYIVHKEFDDDTYDNDIALLQLKSDSSRCAQESSVVRTVCLPPADLQLPDWTECELSGYGKHEALSPFYSERLKEAHVRLYPSSRCTSQHLLNRTVTDNMLCAGDTRSGGPQANLHDACQGDSGGPLVCLNDGRMTLVGIISWGLGCGQKDVPGVYTKVTNYLDWIRDNMRPGGGGSHHHHHHHHHH. |
| Expression System | HEK293 |
| Molecular Weight | 29.8 kDa (reducing) |
| Purity | ＞95% by SDS-PAGE |
| Endotoxin | <1EU/μg |
| Conjugation | Unconjugated |
| Tag | His Tag |
| Physical Appearance | Lyophilized Powder |
| Storage Buffer | 0.2M PBS, pH7.4 |
| Reconstitution | Reconstitute at less than 1 mg/mL according to the size in deionized water after rapid centrifugation. |
| Stability & Storage | Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃ Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles. |
Background
t-PA (tissue plasminogen activator) is a serine protease that hydrolyzates fibrinogen into fibrinolytic enzyme, which plays an important role in fibrinolytic system and maintenance of extracellular matrix homeostasis.t-PA can be high affinity to thrombus matrix and activate fibrinase at the site of thrombus to produce bioactive fibrinase, so as to hydrolyze fibrin， resulting in dissolving thrombus and recanalizing blood vessels without causing systemic activation of fibrinolysis and greatly reducing the risk of hemolysis. It is a specific medicine for the treatment of acute myocardial infarction and other thrombotic diseases.t-PA also exists in the central nervous system and is involved in the occurrence and development of diseases including epilepsy, cerebral ischemia and sciatic nerve injury, as well as a variety of physiological processes including brain learning and memory function, nervous system development and so on.In addition, as a cytokine, T-PA also participates in the pathogenesis of renal interstitial fibrosis through a variety of mechanisms.This product is the recombinant human t-PA protein expressed from human 293 cells (HEK293).
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